Amgydalocortical connectivity at rest is associated with increased reactivity to social threat, ACTH, and future ethanol self-administration

Aggression and anxiety are linked to heavier alcohol use and these phenotypes are associated with dysregulated corticolimbic circuitry and HPA function. Prior to ethanol self-administration, male and female rhesus macaques underwent the Human Intruder Test to assess aggressive and anxious behavior and MRI imaging to assess resting state functional connectivity (rsFC) between the amygdala and prefrontal cortex. Basal cortisol and ACTH were also assayed. After induction of ethanol self-administration with a schedule-induced polydipsia procedure, 4% w/v ethanol access was available for 22 hours/day.

Source: Alcohol - May 1, 2017 Category: Addiction Authors: Megan N. McClintick, Damien Fair, Christopher Kroenke, Kathleen A. Grant Source Type: research