Epigenetic enzymes as a novel class of targets for disease-modifying pharmacotherapies in alcohol addiction

Alcohol dependence leads to escalation of alcohol intake, increased aversion-resistant alcohol taking ( “compulsivity”), and increased sensitivity to stress-induced relapse. We have shown that the emergence of these traits is in part driven by a coordinated and persistent dysregulations of gene expression networks in the medial prefrontal cortex (mPFC). Recently, we identified several novel candid ates that might be mechanistically related to alcohol-addiction relevant phenotypes, and offer targets for disease-modifying pharmacotherapies.

Source: Alcohol - May 1, 2017 Category: Addiction Authors: E. Barbier, A.L. Johnstone, B.B. Khomtchouk, J.D. Tapocik, C. Pitcairn, F. Rehman, E. Augier, A. Borich, J.R. Schank, C.A. Rienas, D.J. Van Booven, H. Sun, D. N ätt, C. Wahlestedt, M. Heilig Source Type: research