Integrative analysis of human and non-human primate brain tissue for alcohol consumption

Alcohol abuse is a significant worldwide socioeconomic problem. Unbiased systems-based approaches assist in the identification of causal mechanisms for the manifestation, progression, and maintenance of disease. An in-depth RNA-Seq study of human and rhesus macaque central amygdala (CEA), a brain region with known involvement in stress and addiction, was conducted to facilitate discovery of novel genes and gene networks underlying lifetime alcohol consumption. The number of genes expressed within postmortem human brain samples was comparable to those genes reliable detected in macaques, allowing a comprehensive parallel examination of each transcriptome.
Source: Alcohol - Category: Addiction Authors: Source Type: research