Brain transcriptional changes in the mouse and macaque associated with excessive ethanol consumption

Extensive data are now available for the transcriptional features associated with the risk of developing and/or the consequences of excessive ethanol consumption and withdrawal. Data have been collected in flies, mouse, rat, macaque and human samples. One assumes that there will be conservation of these transcriptional features. Here we examine a subset of these data focusing on mice selectively bred from heterogeneous stock (HS) for ethanol preference (2-bottle choice) or for high drinking in the dark (HDID) and on both rhesus and cynomolgus macaques chronically exposed to ethanol (choice consumption).

Source: Alcohol - May 1, 2017 Category: Addiction Authors: R. Hitzemann, O. Iancu, A. Colville, P. Darakjian, D. Oberbeck, N. Walter, S. McWeeney, C. Zheng, J. Daunais, John Crabbe, P. Metten, K. Grant Source Type: research