CRF modulation in VTA-DRN escalates alcohol intake after social stress

Victims of aggression undergo neuroadaptive changes that escalate alcohol self-administration in rodent models of drug abuse. CRF modulation of microcircuits comprising control from the mPFC to VTA and DRN are candidate mechanisms for these long-lasting neuroadaptations. Our hypothesis examines the role of extra-hypothalamic CRF in victims of aggression who consume large amounts of alcohol. Pharmacogenetic and optogenetic challenges and microdialysis point to a critical role of CRF modulation of DA in the VTA.
Source: Alcohol - Category: Addiction Authors: Source Type: research