Translational FDG-PET studies in alcohol and cocaine addicted rats

[18F]-FDG PET studies in alcoholics have consistently reported decreases in overall brain glucose metabolism at rest and following acute alcohol administration. However, the time course of cerebral glucose utilization in the transition to addictive behavior is not known and requires longitudinal translational imaging studies in animal models of alcoholism. Here, we studied brain glucose uptake in a DSM-based animal model of alcohol addiction under rest and following alcohol exposure. Acute alcohol administration significantly reduced the whole-brain glucose metabolism in rats.
Source: Alcohol - Category: Addiction Authors: Source Type: research