Choline supplementation attenuates severity of hippocampal BDNF reductions caused by developmental alcohol exposure

Prenatal alcohol exposure alters physical and neurological development, adversely affecting long-term behavior and health. Early nutritional variables are among the factors that can modify ethanol ’s teratogenic effects. We have shown that supplementation with the nutrient choline can attenuate ethanol’s adverse effects on behaviors that depend on the functional integrity of the hippocampus, even when administered after alcohol exposure has ceased. However, it is not fully understood how choline reduces the severity of ethanol’s effects on hippocampal development.
Source: Alcohol - Category: Addiction Authors: Source Type: research