Examining phenotype by treatment interactions in alcohol use disorder clinical trials

Alcohol use disorder (AUD) is a heterogeneous disorder characterized by a variety of developmental etiologies and diverse symptom profiles. Over the past 50+ years many have attempted to characterize types of alcohol drinkers based on behavioral, developmental, and personality aspects. More recent work in the field has focused on genetic and neurobiological markers of risk and AUD treatment response. From this work, there is broad recognition that relief of stress and negative affect (negative reinforcement mechanism) is a primary predictor of relapse among AUD populations.
Source: Alcohol - Category: Addiction Authors: Source Type: research