Exacerbation of the inherent “anxiety” state by unpredictability of alcohol access in Sardinian alcohol-preferring rats

At the last two Volterra meetings this lab has contributed several sets of data on a new experimental procedure of alcohol intake capable of promoting binge-like drinking in selectively bred, Sardinian alcohol-preferring (sP) rats. Specifically, exposure of sP rats to multiple alcohol concentrations (10%, 20%, and 30%, v/v), under the 4-bottle “alcohol vs water” choice regimen, in daily 1-hour drinking sessions with an unpredictable time schedule, resulted in intoxicating intakes of alcohol (≥2 g/kg; BALs≥100 mg%) when the drinking session occurred over the final hours of the dark phase of the light/dark cycle.

Source: Alcohol - May 1, 2017 Category: Addiction Authors: Giancarlo Colombo, Carla Lobina, Irene Lorrai, Paola Maccioni, Gian Luigi Gessa Source Type: research