Effect of the mGluR5 modulator GET 73 on alcohol pharmaco-kinetics and pharmacodynamics and alcohol craving in a human laboratory model

GET 73 is a novel, small molecule compound that reduces alcohol consumption and appears to have some anxiolytic and anti-stress activity in animal models. Although the mechanism of action of GET 73 is not entirely understood, the drug appears to act as a negative allosteric modulator (NAM) at the mGluR5 receptor. mGluR5 NAMs could reduce the hyperglutamatergic / high stress / allostatic state associated with alcohol dependence. To better understand the mechanism of action of GET 73 in reducing alcohol consumption, to examine its potential interactions with alcohol pharmacokinetics and pharmacodynamics, and to determine its safety, we conducted a placebo-controlled, within-subjects crossover study with GET 73.
Source: Alcohol - Category: Addiction Authors: Source Type: research