CeA projections to PAG mediate stress- and alcohol dependence-induced hyperalgesia in rats

Hyperalgesia is an exaggerated response to noxious stimuli resulting from physical insult (e.g., nerve injury) or psychological phenomena. The central amygdala (CeA) receives information from multiple pathways carrying nociceptive information in the central nervous system and projects to regions which gate descending pathways that modulate nociceptive afferent activity, including the periaqueductal gray (PAG). We have recently demonstrated a role for corticotropin-releasing factor (CRF) signaling in CeA in mediating hyperalgesia after stress.

Source: Alcohol - May 1, 2017 Category: Addiction Authors: Elizabeth M. Avegno, Christy A. Itoga, Annie M. Whitaker, Thomas Lobell, Nicholas W. Gilpin Tags: Posters Source Type: research