Chronic ethanol-induced immune responses in the mouse central amygdala: Focus on glia and IL-1 system

In this study, we focused on the chronic ethanol-induced immune response mediated by the innate immune system in the central nucleus of the amygdala (CeA). We used a 2BC-CIE (two-bottle choice - chronic ethanol intermittent vapor exposure) paradigm to induce ethanol dependence in C57BL/6J mice. Using immunohistochemistry, we examined the expression of microglial markers (Iba-1 and CD11b) and morphological changes of microglia in the CeA of ethanol naive, non-dependent and dependent mice.

Source: Alcohol - May 1, 2017 Category: Addiction Authors: Michal Bajo, Michael Q. Steinman, Florence P. Varodayan, Sophia Khom, Reesha R. Patel, David M. Hedges, Melissa A. Herman, Sarah E. Montgomery, Tali Nadav, Noah Steiner, Chitra D. Mandyam, Amanda J. Roberts, Marisa Roberto Source Type: research