Genomic signature of PPAR agonists in mouse amygdala: Role in alcohol consumption

PPARs are nuclear hormone receptors that act as ligand-activated transcription factors. PPAR agonists are used to treat hyperlipidemia and diabetes, and are neuroprotective, hepatoprotective and decrease nicotine and alcohol self-administration. We used an unbiased genomic screen to characterize the gene expression profile induced in the mouse amygdala, a key brain region for alcohol dependence, by two PPAR agonists that are effective (fenofibrate and tesaglitazar) and one that is non-effective (bezafibrate) at reducing alcohol consumption.
Source: Alcohol - Category: Addiction Authors: Source Type: research