Alcohol dependence alters substance P/neurokinin 1 receptor signaling in the central nucleus of the amygdala

Substance P (SP)/neurokinin 1 (NK-1) receptor signaling is critically involved in alcoholism. In animal models, NK-1 receptor knockouts exhibit reduced ethanol consumption; in human detoxified alcoholics, NK-1 receptor antagonists suppress alcohol cravings. However, there are no studies on cellular alterations of SP/NK-1 receptor signaling induced by ethanol dependence.

Source: Alcohol - May 1, 2017 Category: Addiction Authors: S. Khom, K.C. Rice, M. Roberto Source Type: research