Oxytocin decreases central amygdala GABAergic signaling in na ïve but not alcohol dependent rats

Alcohol use disorders (AUDs) are characterized by compulsive seeking and consumption of alcohol. AUDs have been linked to disruption of brain stress systems, as the transition to dependence recruits these systems leading to negative withdrawal states; the relief of which drives further drinking. The central nucleus of the amygdala (CeA) functions as a neuropeptidergic hub of stress and anxiety processing, and GABAergic signaling within the CeA is involved in the regulation of alcohol consumption.
Source: Alcohol - Category: Addiction Authors: Source Type: research