Binge-like alcohol exposure during adolescence has circuit specific effects on dopaminergic neurotransmission in the adult prefrontal cortex

The prefrontal cortex (PFC) is critically involved in cognitive function and inhibitory control. Adolescence represents a critical period of continued development of this region that parallels the maturation of its cognitive function. This extended period of developmental plasticity is thought to render the PFC, and its underlying circuitry, especially vulnerable to environmental insults that may result in deficits that persist well into adulthood. Alcohol drinking typically begins during adolescence when consumption of large quantities, in binge-like episodic patterns, is common.
Source: Alcohol - Category: Addiction Authors: Source Type: research