Age-related effects of restraint stress on ethanol intake

Several work has suggested that adolescents may be significantly more sensitive to stress, and to ethanol-stress interactions, than adults. It is thus important to analyze stress-reactive drinking during adolescence and potential treatments to ameliorate it. Stress effects upon ethanol intake in animal rat models have been controversial, with studies indicating heightened, decreased or unaltered ethanol intake after stress. The present study analyzed the impact of chronic restraint stress (5 daily, 2h long, sessions) upon ethanol intake, assessed across two-weeks via intermittent, 18-h two bottle intake tests, in male and female adolescent and adult rats.

Source: Alcohol - May 1, 2017 Category: Addiction Authors: Aranza Wille-Bille, Ana Ferreyra, Martina Sciangula, Ricardo Pautassi Source Type: research