Family history density of alcoholism and blood pressure as moderators for drinking reduction in alcohol-dependent individuals treated with doxazosin

Background: The α1 receptor antagonist, prazosin has been shown to reduce Posttraumatic Stress Disorder (PTSD) symptoms and studies have revealed that pre-treatment blood pressure (BP) predicts therapeutic response for prazosin in PTSD patients. Furthermore, targeting the norepinephrine system may be a favorable t reatment strategy since evidence demonstrates that prazosin may reduce drinking in alcohol dependent (AD) patients. We investigated how doxazosin, another α1 receptor antagonist with a more favorable pharmacokinetic profile than prazosin, would be moderated by family history density (FHDA) and BP.
Source: Alcohol - Category: Addiction Authors: Source Type: research