The Nociceptin/Orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: Validation in rat models

Introduction: Alcoholism is a complex disorder in which diverse pathophysiological processes contribute to the initiation and progression, resulting in a high degree of heterogeneity among patients. Few pharmacotherapies are presently available, and patient responses to these are variable. The Nociceptin/Orphanin FQ (NOP) receptor has been suggested to play a role both in alcohol reward and in negatively reinforced alcohol seeking. Previous studies have shown that NOP receptor activation reduces alcohol intake in genetically selected alcohol preferring as well as alcohol dependent rats.

Source: Alcohol - May 1, 2017 Category: Addiction Authors: Abdul Maruf Asif Aziz, Shaun Brothers, Gregory Sartor, Markus Heilig, Claes Wahlestedt, Annika Thorsell Source Type: research