Changes in anxiety-like behavior and CRF gene expression in the basolateral amygdala of Lim-domain-only 3 (Lmo3) knockout mice

The LIM-domain only protein LMO3 is a transcriptional regulator that we have shown regulates behavioral responses to alcohol. Specifically, Lmo3 knockout (Lmo3KO) mice exhibit increased ethanol consumption, enhanced ethanol-induced sedation, and altered cocaine and ethanol reward. Due to the high comorbidity of alcohol use and anxiety, we investigated anxiety-like behavior in Lmo3KO mice using the elevated plus maze (EPM) and novelty-induced hypophagia tasks. We next explored the mechanism by which LMO3 may be regulating anxiety by measuring expression levels of CRF and its receptor type 1 in Lmo3KO and wildtype mice.
Source: Alcohol - Category: Addiction Authors: Source Type: research