Mathematical modeling of ethanol/stress interactions

While it is well established that stress and alcohol use are mutually related, intricate molecular mechanisms through which ethanol alters the organism ’s response to stress remain only partially understood. To study the complex interactions between ethanol and stress, we have developed a stoichiometric network model to succinctly describe complex birhythmic changes in blood levels of steroid and peptide hormones that constitute the hypothalamic– pituitary–adrenal (HPA) axis and use numerical simulations and approaches from dynamical systems theory to investigate how HPA axis dynamics is affected by acute and chronic ethanol challenge.

Source: Alcohol - May 1, 2017 Category: Addiction Authors: Željko Čupić, Ana Stanojević, Vladimir M. Marković, Ljiljana Kolar-Anić, Lars Terenius, Vladana Vukojević Source Type: research