Nicotinamide adenine einucleotide reverses hepatic molecular chaperones abnormalities and alleviates experimental alcoholic steatohepatitis in mice

Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase that maintains liver homeostasis and hepatic metabolic function. One of the key intermediate of NAD+ is nicotinamide mononucleotide (NMN). The aim of the present study was to test the ability of NMN to reverse ethanol-mediated aberrant SIRT1 signaling by using wild-type (WT) and liver-specific SIRT1 knockout (Sirt1LKO) mice. Utilizing the Gao-binge ethanol feeding protocol, eight groups of matched WT and Sirt1LKO mice were pair-fed ethanol containing or control diets.

Source: Alcohol - May 1, 2017 Category: Addiction Authors: Y. Han, C. Kim, A. Jogasuria, X. Hu, J. Wang, H. Shen, J. Wu, M. You Source Type: research