Adolescent social isolation differentially affects synaptic function and plasticity along the dorsoventral axis of the hippocampus

Prior work by our laboratory and others have demonstrated that a rodent model of adolescent social isolation stress (aSI) produces robust and persistent increases in phenotypes relevant to alcohol addiction, including increased anxiety-like behaviors and ethanol consumption. Recent work suggests that the basolateral amygdala (BLA) and the hippocampus —the ventral domain of the hippocampus (vHC), in particular—are critical components of a distributed network that subserves the processing of stimuli and the gating of behavioral responses underlying stress, fear, and anxiety-like behaviors.
Source: Alcohol - Category: Addiction Authors: Source Type: research