Assessing the contribution of somatostatin-positive interneurons in the drinking in the dark binge-like ethanol consumption model

Alcoholism and major depressive disorder (MDD) are highly comorbid disorders, both of which are major health and social concerns —costing the US a combined $300 billion each year. To date, there has yet to be a comprehensive strategy for effectively preventing, treating, or managing either of these highly prevalent and detrimental disorders. In order to create better treatments, we need a deeper understanding of the brain r egions involved and the contributions of specific neuronal subtypes. Somatostatin (SST)-expressing interneurons of the human forebrain have been implicated in MDD based on gene expression changes found in postmortem human brain studies.
Source: Alcohol - Category: Addiction Authors: Source Type: research