Beta-endorphin modulates binge-like ethanol drinking in mice

Binge alcohol drinking is a widespread problem in the Unites States and has been linked to an increased risk for alcohol-related complications including the development of alcohol use disorders and alcoholism (King et al, 2011). Therefore, understanding the neural antecedents of binge drinking could elucidate underlying mechanisms and facilitate identification of potential therapeutic targets to prevent the transition from binge drinking to alcoholism. Beta-endorphin (B-E), an endogenous opioid peptide, has long been documented as a risk factor for alcoholism due in part to low basal plasma levels and an increased B-E response to alcohol observed in at-risk subjects (Gianoulakis et al, 1996).

Source: Alcohol - May 1, 2017 Category: Addiction Authors: Todd B. Nentwig, Colleen E. McGonigle, Diane E. Wilson, Erin M. Rhinehart, Judith E. Grisel Source Type: research