Restoration of Kv7.2/7.3 channel signaling reduces dependence-induced escalation of ethanol consumption

Alcohol (ethanol) dependence is a chronic relapsing brain disorder characterized by uncontrollable, heavy alcohol consumption. Emerging evidence suggests that the expression and function of several potassium (K+) channels, including Kv7 channels, are dysregulated in the post-dependent state. Kv7 channels regulate intrinsic excitability and dependence-induced changes may reduce their capacity to regulate neuronal firing contributing to hyperexcitability during periods of ethanol withdrawal. Additionally, chronic ethanol consumption alters Kv7.2 channel trafficking, and systemic administration of FDA approved Kv7 channel opener, retigabine, reduces ethanol consumption in nondependent, high-drinking rats and mice.

Source: Alcohol - May 1, 2017 Category: Addiction Authors: Jennifer A. Rinker, Patrick J. Mulholland Source Type: research