Effect of SB-277011-A, a D3 selective antagonist, on resting state functional connectivity in Wistar rats

The mesolimbic dopamine system plays an important role in mediating addiction to alcohol and other drugs of abuse. Just recently, a growing body of evidence emerged showing that the dopamine D3 receptor subtype is significantly involved in mechanisms of alcohol intake, as well as cue- and drug-triggered reinstatement of alcohol-seeking. Moreover, data from the literature showed that resting state connectivity within and between the reward system and the cognitive control system is compromised in alcoholics.
Source: Alcohol - Category: Addiction Authors: Source Type: research