Genome-wide profiling of differentially spliced mRNAs in human fetal cortical tissue exposed to alcohol

Excessive alcohol consumption results in significant changes in gene expression and isoforms due to altered mRNA splicing. As such, an intriguing possibility is that disturbances in alternative splicing are involved in key pathological pathways triggered by alcohol exposure. However, no resources have been available to systematically analyze this possibility at a genome-wide scale. Here, we performed RNA sequencing of human fetal cortical slices that were obtained at the late first trimester and exposed to ethanol or control medium.

Source: Alcohol - May 3, 2017 Category: Addiction Authors: Yuka Imamura Kawasawa, Shahid Mohammad, Alexander I. Son, Hiroki Morizono, Aiesha Basha, Anna C. Salzberg, Masaaki Torii, Kazue Hashimoto-Torii Source Type: research