A global perspective on FOXO1 in lipid metabolism and lipid-related diseases

Publication date: April 2017 Source:Progress in Lipid Research, Volume 66 Author(s): Yue Li, Zhiqiang Ma, Shuai Jiang, Wei Hu, Tian Li, Shouyin Di, Dongjin Wang, Yang Yang Lipid metabolism is a complex physiological process that is involved in nutrient adjustment, hormone regulation, and homeostasis. An unhealthy lifestyle and chronic nutrient overload can cause lipid metabolism disorders, which may lead to serious lipid-related diseases, including obesity, non-alcoholic fatty liver disease (NAFLD), and type 2 diabetes mellitus (T2DM). Therefore, tools for preventing dysfunctional lipid metabolism are urgently needed. The transcription factor forkhead box protein O1 (FOXO1) is involved in lipid metabolism and plays a critical role in the development of lipid-related diseases. In this review, we provide a global perspective on the role of FOXO1 in lipid metabolism and lipid-related diseases. The information included here may be useful for the design of future studies and advancing investigations of FOXO1 as a therapeutic target.
Source: Progress in Lipid Research - Category: Lipidology Source Type: research