Interleukin-1 β as emerging therapeutic target in hematological malignancies and potentially in their complications

Interleukin-1 β (IL-1β) is a pleiotropic cytokine that exerts multiple roles in both physiological and pathological conditions. It is produced by different cell subsets, and drives a wide range of inflammatory responses in numerous target cells. Enhanced IL-1β signaling is a common event in patients of hematol ogical malignancies. Recent body of evidence obtained in preclinical models shows the pathogenic role of these alterations, and the promising therapeutic value of IL-1 targeting. In this review, we further highlight a potential contribution of IL-1β linking to complications and autoimmune disease t hat should be investigated in future studies.
Source: Blood Reviews - Category: Hematology Authors: Tags: Review Source Type: research