Thrombogenicity Testing of Medical Devices in a Minimally Heparinized Ovine Blood Loop

This study describes an in vitro assay that integrates freshly harvested ovine blood containing minimal heparin in a closed pumped loop. To confirm the reproducibility of this assay, control materials were identified that elicited either a positive or a negative thrombogenic response. These controls demonstrated reproducibility in the resulting thrombogenicity scores with median scores of 5 and 0 for the positive and negative controls, respectively, which also demonstrated a significant difference (p  

Source: Journal of Medical Devices, Transactions of the ASME - May 3, 2017 Category: Medical Equipment Source Type: research