Abstract A21: Enhancing chemotherapeutic responses in CNS malignancy through suppression of hyperactive DNA damage repair pathways
Conclusion: I have identified unique DNA repair enzymes, which may mediate specific differential chemo-radioresistant phenotypes in MB and MG. An expanded analysis is currently underway to further differentiate DNA repair mechanisms and therapeutic responses between these two brain tumor types. I hope to translate these findings into pre-clinical models whereby my data may lead to identifying next-generation brain cancer treatments with improved patient survival and quality-of-life.Citation Format: Marina Mostafizar, Sachin Katyal. Enhancing chemotherapeutic responses in CNS malignancy through suppression of hyperactive DNA damage repair pathways [abstract]. In: Proceedings of the AACR Special Conference on DNA Repair: Tumor Development and Therapeutic Response; 2016 Nov 2-5; Montreal, QC, Canada. Philadelphia (PA): AACR; Mol Cancer Res 2017;15(4_Suppl):Abstract nr A21.
Source: Molecular Cancer Research - Category: Cancer & Oncology Authors: Mostafizar, M., Katyal, S. Tags: Synthetic Lethality and Viability: Poster Presentations - Proffered Abstracts Source Type: research
More News: Ataxia | Brain | Brain Cancers | Brain Tumor | Cancer | Cancer & Oncology | Child Development | Childhood Cancer | Conferences | Gastroschisis Repair | Genetics | Glioma | Medulloblastoma | Neurology | Study