Abstract B12: Effect of Ganoderma lucidum on DNA damage and DNA repair in colorectal cancer cell lines

Colorectal carcinoma (CRC) is the third most common type of cancer in the world and second most common cause of cancer related deaths in Europe. Countries of Central Europe (Czech Republic, Slovakia and Hungary) have one of the highest rates both for incidence and mortality of CRC and this disease therefore possesses a serious health, social and economic problem.CRC is a complex disease that develops as consequence of environmental and health risk factors with particular involvement of suboptimal DNA repair, resulting in accumulation of DNA damage. Reactive oxygen species (ROS) represent a group of highly reactive molecules tightly controlled by cellular antioxidant system. Disturbance of the prooxidation–antioxidation homeostasis can lead to ROS accumulation and consequently to DNA damage and apoptosis. Many natural compounds possess anti-cancer activities with the generation of ROS. Cancer cells are more sensitive to oxidative DNA damage than non-malignant cells. Modulation of oxidative DNA damage and DNA repair pathways by natural compounds may lead to selective cancer cell-death and to sensitization of cancer cells to treatment. Ganoderma Lucidum (GLC) (Reishi, Ling-Zhi) is a mushroom used in Chinese medicine for thousands of years for prevention or therapy of many different disorders including cancer.The aim of our study is to define the effect of Ganoderma lucidum (GLC) extract on DNA damage and DNA repair machinery in colorectal cancer cell lines (HTC116, HCT116p...
Source: Molecular Cancer Research - Category: Cancer & Oncology Authors: Tags: DNA Damage Signaling: Poster Presentations - Proffered Abstracts Source Type: research