Hypoxia inhibits expression and function of mitochondrial thioredoxin 2 to promote pulmonary hypertension

In conclusion, Trx2 overexpression failed to attenuate hypoxia-induced HPASMC proliferation in vitro or hypoxia-induced PH in vivo. These findings indicate that strategies to enhance Trx2 expression are unlikely to exert therapeutic effects in PH pathogenesis.

Source: AJP: Lung Cellular and Molecular Physiology - May 1, 2017 Category: Respiratory Medicine Authors: Adesina, S. E., Wade, B. E., Bijli, K. M., Kang, B.-Y., Williams, C. R., Ma, J., Go, Y.-M., Hart, C. M., Sutliff, R. L. Tags: RESEARCH ARTICLE Source Type: research