High-throughput screening identifies microRNAs that target Nox2 and improve function after acute myocardial infarction

In conclusion, our results show that miR-106b, miR-148b, and miR-204 were able to improve heart function after myocardial infarction in mice by targeting Nox2 and possibly altering inflammatory cytokine production. This screening system and delivery method could have broader implications for miRNA-mediated therapeutics for cardiovascular and other diseases.
NEW & NOTEWORTHY NADPH oxidase (Nox)2 is a promising target for treating cardiovascular disease, but there are no specific inhibitors. Finding endogenous signals that can target Nox2 and other inflammatory molecules is of great interest. In this study, we used high-throughput screening to identify microRNAs that target Nox2 and improve cardiac function after infarction.

Source: AJP: Heart and Circulatory Physiology - May 1, 2017 Category: Cardiology Authors: Yang, J., Brown, M. E., Zhang, H., Martinez, M., Zhao, Z., Bhutani, S., Yin, S., Trac, D., Xi, J. J., Davis, M. E. Tags: RESEARCH ARTICLE Source Type: research