Abstract PR07: Comparison of risk model recommendations for women at high-risk of breast cancer based on clinical thresholds using the Prospective Family Study Cohort (ProF-SC)

Conclusion: These results suggest that there is a considerable discordancy between two commonly used risk models to determine high risk classification for MRI and chemoprevention. There is a greater concordancy between the two models when using a shorter time-horizon, especially for women over the age of 50 years. However, as MRI and chemoprevention for high-risk women often needs to start before the age of 50 years, there is a great need to enhance risk assessment for these younger high risk women.Citation Format: Mary Beth Terry, Kelly-Anne Phillips, Yuyan Liao, Robert J. MacInnis, Gillian S. Dite, Mary B. Daly, Esther M. John, Irene L. Andrulis, Saundra S. Buys, Richard Buchsbaum, John L. Hopper. Comparison of risk model recommendations for women at high-risk of breast cancer based on clinical thresholds using the Prospective Family Study Cohort (ProF-SC). [abstract]. In: Proceedings of the AACR Special Conference: Improving Cancer Risk Prediction for Prevention and Early Detection; Nov 16-19, 2016; Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(5 Suppl):Abstract nr PR07.
Source: Cancer Epidemiology Biomarkers and Prevention - Category: Cancer & Oncology Authors: Tags: Improving Cancer Risk Prediction for Prevention and Early Detection: Oral Presentations - Proffered Abstracts Source Type: research