Perineural Invasion and Risk of Lethal Prostate Cancer

Conclusions: These data support the hypothesis that perineural invasion creates a microenvironment that promotes cancer aggressiveness.
Impact: Our findings suggest that PNI should be a standardized component of histopathologic review, and highlights a mechanism underlying prostate cancer metastasis. Cancer Epidemiol Biomarkers Prev; 26(5); 719–26. ©2017 AACR.

Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Zareba, P., Flavin, R., Isikbay, M., Rider, J. R., Gerke, T. A., Finn, S., Pettersson, A., Giunchi, F., Unger, R. H., Tinianow, A. M., Andersson, S.-O., Andren, O., Fall, K., Fiorentino, M., Mucci, L. A., on behalf of the Transdisciplinary Prostate Cancer Tags: Research Articles Source Type: research