Cytokeratin 7 in Oropharyngeal Squamous Cell Carcinoma: A Junctional Biomarker for Human Papillomavirus-Related Tumors

Conclusions: An association between CK7 and HPV has been demonstrated. CK7-expressing tonsillar crypt cells potentially represent an oropharyngeal subsite susceptible to HPV-related SCC. Impact: Along with the cervix and anorectum, specific oropharyngeal expression of CK7 in a site predisposed to HPV-related tumors may suggest a role for CK7 in the pathogenesis of this subgroup of tumors. Further research is warranted to characterize the association between CK7 and HPV-related head and neck SCC. Cancer Epidemiol Biomarkers Prev; 26(5); 702–10. ©2017 AACR.

http://cebp.aacrjournals.org/cgi/content/short/26/5/702?rss=1

Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Woods, R. S. R., Keegan, H., White, C., Tewari, P., Toner, M., Kennedy, S., O'Regan, E. M., Martin, C. M., Timon, C. V. I., O'Leary, J. J. Tags: Research Articles Source Type: research