Immunomodulatory and antiarthritic activities of Smilax zeylanica

This study was designed to investigate the immunomodulatory and antiarthritic activities ofSmilax zeylanica.Methanolic extract ofSmilax zeylanica(MESZ) roots was tested for its immunomodulatory activity by NBT reduction test. Antiarthritic activity of the same was tested byin vitroprotein denaturation andin vivocomplete Freunds adjuvant (CFA) induced arthritis.MESZshowed its significant effect on both cell mediated and humoral immunity to suppress stimulated immune responses in NBT reduction test . It also markedly inhibited protein denaturation inin vitromodel. Extract at 200 mg/kg and 400 mg/kg showed statistically significant inhibition ( p<0.05) of the edema formation in CFA model. Histopathological studies of ankle joints also supported this finding.The presence of steroids in the extract might be responsible for the prominent immunomodulatory and antiarthritic activities of the plant. Hence the present study concluded thatSmilax zeylanica holds immunomodulatory and antiarthritic activities.
Source: International Journal of Phytomedicine - Category: Science Authors: Source Type: research