The in vivo evidence for regulated necrosis

Conclusions based on such work might not necessarily be transferrable to disease states in which synchronized, non‐cell autonomous effects occur. Here, we summarize the current knowledge of the pathophysiological relevance of necroptosis in vivo, and in light of this understanding, we reassess the morphological classification of necrosis that is generally used by pathologists. Along these lines, we discuss the paucity of data implicating necroptosis in human disease. Finally, the in vivo relevance of non‐necroptotic forms of necrosis, such as ferroptosis, is addressed.
Source: Immunological Reviews - Category: Allergy & Immunology Authors: Tags: INVITED REVIEW Source Type: research