Use of a novel docosahexaenoic acid formulation vs control in a neonatal porcine model of short bowel syndrome leads to greater intestinal absorption and higher systemic levels of DHA

The objective of this study was to evaluate in a porcine model of SBS, the systemic absorption of a novel enteral Docosahexaenoic acid (DHA) formulation that forms micelles independent of bile salts (DHA-ALT ®). We hypothesized that enteral delivery of DHA-ALT® would result in higher blood levels of DHA compared to a control DHA preparation due to improved intestinal absorption. SBS was induced in term piglets through a 75% mid-jejunoileal resection and the piglets randomized to either DHA-ALT® or co ntrol DHA formulation (N=5 per group) for 4 postoperative days.

Source: Nutrition Research - February 4, 2017 Category: Nutrition Authors: Camilia R. Martin, Barbara Stoll, Joanne Cluette-Brown, Adesola C. Akinkuotu, Oluyinka O. Olutoye, Kathleen M. Gura, Pratibha Singh, Munir M. Zaman, Michael C. Perillo, Mark Puder, Steven D. Freedman, Doug Burrin Tags: Original Research Source Type: research