G protein-coupled receptors: Novel probe for MRGPRX2

Nature Reviews Drug Discovery 16, 314 (2017). doi:10.1038/nrd.2017.77 Author: Crunkhorn Sarah The orphan MAS-related G protein-coupled receptor member X2 (MRGPRX2) is expressed primarily in human dorsal root ganglia and mast cells, and has been suggested to modulate pain and itch. Using a high-throughput screen of 5,695 unique compounds, Lansu et al. discovered that many exogenous
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research