Antibiotics: Reversing resistance

Nature Reviews Drug Discovery 16, 314 (2017). doi:10.1038/nrd.2017.74 Author: Crunkhorn Sarah Acquired Mycobacterium tuberculosis resistance to the commonly used antibiotic ethionamide (ETH) is mediated by mutations in the bacterial enzymatic pathway that is required for biological activation of the drug. Here, Blondiaux et al. identify a series of spiroisoxazoline compounds — named small molecules
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research