Alcohol induces epigenetic immunomodulation of human monocyte-derived dendritic cells

Epigenetic mechanisms have been shown to play a role in alcohol use disorders (AUDs) and may prove to be valuable therapeutic targets. Our group is interested in studying the epigenetic mechanisms involved in the modulation of alcohol-induced oxidative stress and inflammation in human primary monocyte-derived dendritic cells (MDDCs). Therefore, in the current study, the role of histone deacetylases (class I HDACs) and histones (H3 and H4) in peripheral inflammation and the epigenetic mechanisms of alcohol-induced oxidative stress were analyzed ex vivo and in vitro.

Source: Alcohol - March 1, 2017 Category: Addiction Authors: M. Agudelo Source Type: research