Alcohol exacerbates an ulcerative colitis flare period

Ulcerative colitis (UC) is a cyclical, life-long illness characterized by disease remission and active disease flares causing abdominal pain, weight loss, intestinal inflammation, rectal bleeding, and dehydration. We sought to determine whether alcohol exposure exacerbates UC flare period. Male C57BL/6 were divided into two groups: dextran sodium sulfate (DSS) and sham. In DSS group, mice received 2% DSS ad libitum in their drinking water for 5 days to induce UC. Mice in sham received water. On day 5, mice in DSS and sham group were subdivided into two subgroups: mice gavaged with alcohol ( ∼3g/kg) or with water on days 5, 6, and 7.
Source: Alcohol - Category: Addiction Authors: Source Type: research