Alcohol, brain neuroimmune/inflammatory signaling, and neurodamage

Chronic alcohol (ethanol) abuse is a major and yet underappreciated facilitative reason world-wide for adult brain damage and dementia. Accumulating experimental evidence indicates that severe, repetitive binge alcohol exposure evokes a cascade of brain processes involving neuroinflammatory and neuroimmune molecules which trigger oxidative stress, synaptic loss and/or neurodegeneration. We have examined these signaling processes using in vivo and in vitro models (adult rats and adult-age rat brain organotypic slice cultures) subjected to binge alcohol intoxication over several days.
Source: Alcohol - Category: Addiction Authors: Source Type: research