Butyrate protects intestinal immune response during chronic-binge ethanol exposure

Following injury, an immune response needs to be adequately mounted and resolved for proper organ function homeostasis. Immune responses following exposure to ethanol (EtOH) differ. While chronic EtOH exposure is pro-inflammatory, acute EtOH can dampen immune responses. Since butyrate, a fermentation byproduct of the gut microbiota, influences gut inflammation and immunity, we studied the butyrate ’s impact on intestinal innate immune responses following chronic-binge EtOH exposure. C57BL/6J mice exposed to 5% v/v EtOH-containing diet for 10 days received a single EtOH gavage (5g/kg) 9 hrs prior to euthanasia.

Source: Alcohol - March 1, 2017 Category: Addiction Authors: G.A. Cresci, B. Glueck, L.E. Nagy Source Type: research