Mechanistic role of Per2 and PPAR-gamma in ethanol mediated hyperpermeability

This study examined mechanisms of ethanol induced intestinal permeability using an in vitro model of the intestinal epithelium. The circadian clock regulates the intestinal barrier function. Chronic ethanol exposure increases the expression of circadian protein Per2 that is required to increase leakiness through a mechanism that is not fully characterized. Peroxisome proliferator-activated receptor gamma (PPAR-gamma) has been closely associated with intestinal barrier recovery. Research suggests that oxidative stress may disrupt nucleocytoplasmic trafficking of circadian proteins.

Source: Alcohol - March 1, 2017 Category: Addiction Authors: B.T. Davis, M. Shaikh, C.B. Forsyth, A. Keshavarzian Source Type: research