PPAR- γ agonists suppress neuroinflammation in a FASD animal model

Fetal Alcohol Spectrum Disorders (FASD) result from maternal alcohol consumption, and can lead to developmental abnormalities, including those in the central nervous system (CNS). FASD is associated with lifetime disabilities and is the leading cause of mental retardation in the U.S. There are no effective treatments for FASD. Using our third trimester-equivalent mouse model of FASD, in which postnatal day 4-9 mice are treated with 4 g/kg ethanol per day via intra-esophageal gavage, we demonstrated that ethanol produces both loss of neurons and microglia.

Source: Alcohol - March 1, 2017 Category: Addiction Authors: P.D. Drew, J.C. Douglas, J.W. Johnson, K.D. Phelan, C.J.M. Kane Source Type: research