IL-18 inhibition protects intestines from excessive inflammation independent of IL-22 administration following alcohol and burn injury

Excessive consumption of alcohol has been shown to increase the incidence of traumatic injury, including burn injury. Previous studies in hospitalized patients have found those who have consumed alcohol prior to burn injury have higher incidence of infection, multiple organ failure, and mortality. We have also observed substantial increases in inflammatory markers IL-6, KC, and IL-18 in the small intestine of mice following alcohol and burn injury. However, the mechanisms of how alcohol exacerbates post-burn pathogenesis remain elusive.

Source: Alcohol - March 1, 2017 Category: Addiction Authors: A.M. Hammer, N.L. Morris, A.R. Cannon, R.C. Gagnon, P.V. Kuprys, X. Li, M.A. Choudhry Source Type: research